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Spencer Smythe is a character that appears in LEGO Spider-Man: The Videogame.
Spencer Smythe was hired by industralist Norman Osborn as a weapon to destroy Spider-Man. Spencer's first weapon was the Spider-Slayer, nicknamed the "Black Widow". The deal made with Osborn meant that Norman would build a hoverchair for Spencer's paralyzed son, Alistair. The Slayer unintentionally captured Flash Thompson dressed as Spider-Man, and the real Spider-Man came to his resuce.
This led to a large scale fire in the Oscorp plant. When Osborn refused to build the promised hoverchair, Spencer chose to stay behind and finish Spider-Man off while Norman got Alistair to safety. After the Slayer was destroyed by Spider-Man, Oscorp exploded and Spencer perished. However, Spencer had survived, having been found by the Kingpin.
The Kingpin placed Spencer in cryogenic suspension in order to maintain the loyalty of Alistair. Like most employees of the Kingpin, Alistair outlived his usefulness and was changed into a biomechanical Spider Slayer by Kingpin's new sidekick, Herbert Landon. Alistair eventually discovered that his father was still alive and with Spider-Man's help escaped with his preserved body. Afterwards Smythe continued to work for various villains, most predominantly the Kingpin's rival Silvermane, in order to revive his father.