Jiaying was an Inhuman gifted with the power of life force absorption after experiencing Terrigenesis. Using her abilitiy, Jiaying retained her youthful appearance for several decades by draining the life from a number of Inhumans who had willingly sacrificed themselves for her. Thanks to this, she used her wisdom and experience to guide a number of Inhumans throughout dozens of generations, helping them to cope with their powers, and in time, harness them. She worked in a clinic in China, alongside her husband, Calvin Johnson, and had a daughter whom they named Daisy. Jiaying was captured and vivisected by the HYDRA leader Werner Reinhardt, who believed he had killed her. In truth, her body was found by her husband, who stitched her back together, allowing her healing powers to work.
Her experience with Reinhardt, and the subsequent taking of her daughter by S.H.I.E.L.D., warped Jiaying's moral compass, and she developed a dispassionate attitude towards humanity, which pushed her away from her husband. Eventually, she became the leader of Afterlife, the Inhuman community on Earth, and was reunited with her daughter. She then started an open war against S.H.I.E.L.D., when they approached her for peace. Jiaying's hatred for humans led her to attack her own daughter when she sided with S.H.I.E.L.D.