Misako has a hairpiece that is the same mould that was first used for Princess Tamina's minifigure. Like the other Ninjago characters, her face is yellow. She has black eyebrows, pink lips, eyelashes, wrinkles at the sides of her eyes and glasses with grey rims and round frames. Her hair is medium grey with a light grey streak in it and runs in a braid down her back. She wears a buttoned cream jacket with long sleeves, buttoned pockets in the front, and a brown belt with a gold buckle around the waist. A green ascot is located around her neck. She wears sand-green pants, which have zippered pockets at the front.
When the Ninja visit the Ninjago Museum of History, the workers inform them that the Great Devourer's venom had worked its way through the sewer system of Ninjago City and ended up seeping through into the Museum, resulting in the venom infecting the Museum's merchandise of the Stone Warriors and bringing them to life. While the Ninja are fighting off the toy Stone Warriors, one slips out of the room and down the hallway, and as Sensei Wu follows it he runs into Misako. Lloyd then walks out from the merchandise room to see his mother, and as Misako tries to explain to him that she had her reasons for being away, he refuses to listen to her.
Lloyd heads to another room to be alone, but Misako follows, informing him that she left to do research for the Green Ninja prophecy in hopes of preventing it. The other Ninja arrive, and she begins telling a story of the First Spinjitzu Master that involves the Island of Darkness and the Stone Warriors.
However, in another part of the Museum, the Great Devourer's venom drips from the ceiling onto a Giant Stone Warrior statue, bringing it to life. While Misako is telling them that there is hope to prevent Lord Garmadon and Lloyd's fight, the Stone Warrior rampages through the building and confronts the Ninja. They attempt to fight it off to no avail, to which they flee and run through the Museum as they try to figure out how to defeat it.
They stop inside a large room and close the doors, and while the Stone Warrior breaks it down Lloyd comes up with a plan and tells the Ninja to distract it. Lloyd leaves the room and the Stone Warrior breaks in, Misako deciding to assist Lloyd by leading the Stone Warrior to Lloyd's location. She meets up with him, and Lloyd tricks the Stone Warrior into stepping over the fabricated flooring to reveal the giant sinkhole where it was unearthed. After the warrior falls, Misako tells Lloyd that she is proud of him, and Sensei Wu comes in to ask her to stay with them, to which she accepts.
While Sensei Wu is thoughtfully gazing at a picture of Lord Garmadon, Misako, and himself before Lord Garmadon's banishment, Misako walks in the room commenting on how Lord Garmadon looked before. She hands Sensei Wu a scroll containing her research, and as he looks over it she says that she should have chosen him instead. When he says that is in the past, she replies that there is still the future while holding his hand. However, their moment is interrupted by an earthquake.
At Ninjago City, after the Ninja save a woman from the crumbling earth, Misako realizes that the earthquakes are a sign of the Stone Warrior Army's return.
As the citizens of Ninjago rush into a building to get to the roof in order to escape on the Destiny's Bounty, Dareth bumps into Misako in the rush, making her drop her research scrolls. When they arrive on the roof, Misako attempts to hold Sensei Wu's hand again, only to be separated by the enormous crowd heading toward the Bounty.
Right as the Destiny's Bounty is leaving, Misako remembers her scrolls, saying that they would be too important to lose and heading back down. She spots the scrolls tangled among the wires of the long ceiling lights, though she is met by Stone Warriors and carefully climbs down the wires. Upon obtaining the scrolls she slips while jumping to the railing, and before she falls Sensei Wu grabs her and helps her up. The two run into a room where they are cornered, trying their best to fight off the warriors by using Spinjitzu. Seeing that their efforts were pointless, they decide to escape through the window, only to be caught by Nya on the Destiny's Bounty. Sensei Wu loses the photo in the wind, Misako assuring him that the past is the past.
The ninja prepare the Destiny's Bounty to sail to the Dark Island and find out if Garmadon is there. Misako joins them. On the way, they are attacked by Star Teeth and find Dr. Julien. The Bounty is destroyed, but the doctor repairs it and turns it into a half blimp, half boat. They proceed to the Dark Island. Once there, Misako says that finding the Temple of Light will give the ninja pure elemental powers to defeat the Stone Army. The ninja find the temple, and charge themselves up for the final battle. Misako watches from afar, and says that good may win after all.
Soon after, Misako realizes that returning the Helmet of Shadows to its pedestal in the celestial clock might stop the countdown to the final battle, meaning that Lloyd would not have to fight Garmadon. She then formulates a plan with the four ninja where she would attempt to steal the helmet from Garmadon and return it to the clock. She feigns capture at the hands of the four ninja, who are disguised as Stone Warriors, and is brought before Garmadon. Misako at first tries to convince Garmadon that he can be good and prevent fighting with his son, but Garmadon insists that the final battle is their destiny. He then sets his helmet aside and turns his back towards Misako, talking about how he still loves her and inviting her to join his side, but while he is doing this, Misako silently steals the helmet. She then escapes with the ninja and Nya, who comes to rescue them, in the Power Drill. However, the stone army and Garmadon, who pilots a giant four-armed robot, give pursuit, and Garmadon ends up catching them, but Lloyd destroys his robot before he can do any harm. They are about to face off, and Lloyd has the upper hand, but Lloyd cannot bring himself to harm his father, and the group continues with their journey to the clock.
At the clock, Misako tells the group that they need to find the helmet's pedestal among the clock's complex moving mechanisms, but the clock's complexity coupled with the interference of the stone army delay their attempts. Misako finally is able to find the pedestal and place the helmet on it, and the clock stops. At first, the group believes that they accomplished their mission, but the clock starts again and it is revealed that they were moments too late; the clock's hands point at the symbol representing the final battle, indicating it has started, and the mechanisms line up to reflect a beam of light somewhere across the island. The cliff collapses, separating Nya from the rest of the group and sending the others into the ocean below, though they survive. After exiting the ocean, Jay and Kai want to rescue Nya from the Stone Army, but Misako and Wu tell them that, although that time will come, they must divert all their efforts to preparing Lloyd for the final battle, which could begin at any time.
In Spellbound it's revealed that Chen had Garmadon put his name a love letter to her sent from Wu. That letter was the reason she fell in love with Garmadon.
She realizes the truth in The Corridor of Elders when Chen reveals it and later on she forgave Garmadon for what he did.
- Unlike the show, the official minifigure does not have pockets printed on her legs.
- Ninjago: Masters of Spinjitzu