After Loki was defeated, the Other told his master that to attack the Avengers would be to court death. To this, Thanos simply smiled.
After Loki's failure, Thanos made an agreement with the evil Kree warlord, Ronan the Accuser, to retrieve a cataclysmic orb for him so that he will destroy Xandar for Ronan for the murder of his ancestors. But when Ronan did get the orb and discovered that it contained an Infinity Stone, he called off the deal and kept the power of the orb for himself. He was, however, destroyed by the Guardians of the Galaxy and the stone was contained and locked away by the Nova Corp of Xandar.
Thanos also tasked Ronan with training his two adoptive daughters: Nebula and Gamora. Thanos had destroyed Gamora's planet and had murdered her true parents in front of her and had tortured her, turning her into his "weapon" and making her become his assassin. However, both Nebula and Gamora had betrayed both Ronan and Thanos, while Nebula fled somewhere unknown, Gamora had joined the Guardians.
- Just like all the Big-Figs except for Hulk, he kills a Big-Fig instantly with his power attack.