- "Through the Mystic Arts, we harness energy and shape reality."
- ―The Ancient One to Doctor Strange
In his prime, the Ancient One was a master of the mystic arts, with a vast knowledge of magical lore.He possessed the ability to manipulate the forces of magic for a vast number of effects and was able to tap into extra-dimensional energy by invoking entities or objects of power, existing in dimensions tangential to those of the Earth, through the recitation of spells. The Ancient One was capable of astral projection, levitation, interdimensional teleportation, and a large number of other effects. However, in his extreme old age, the Ancient One was unable to perform any major feats of sorcery without placing great physical strain upon himself.
Ancient One was known as the Sorcerer Supreme and became the Master Of The Mystic Arts. For 700 years, the Ancient One protected Earth from mystical threats, and dedicated herself to helping others in need by educating them in the magical arts to give them new hope.
However, later on, she was challenged by a former student, Kaecilius, who had become corrupted by the Dark Dimension and sought to bring Dormammu to Earth. In the midst of her war with Kaecilius and his Zealots, the Ancient One encountered Doctor Strange and, despite her initial reluctance, was persuaded to accept him as her student by Karl Mordo.
During one final battle, the Ancient One was fatally wounded and despite the best efforts of Doctor Strange and Christine Palmer, she accepted her fate and died, but not before giving Doctor Strange the advice he needed to defeat Dormammu as well as to find his new purpose in life.
- The character is traditionally male in the comics, but is portrayed as female in 2016's Doctor Strange movie. In the movie, the Ancient One is played by Tilda Swinton.
- The Ancient One in the set sports different colors than she has in the film, though the set is based on the film. The set version has a largely purple and orange scheme, while the version in the film is white and light orange.