Ava, the fifth White Tiger, was the sister of Hector Ayala and a student enrolled in the Avengers Academy. She inherited the White Tiger amulet from her brother following the death of him and his family members at the hands of Gideon Mace. Upon her introduction, Ava stated that the White Tiger was a family legacy that she intended to honor. She also criticized classmate Reptil for not being more active in the Hispanic community. She had been living with her sister Awilda's family since the death of her parents.
Ava Ayala is the latest in a long family line of bearers of the legendary White Tiger Amulet. When she wears it, she gains superhuman, cat-like agility and reflexes, although it takes all of her strong will and training to keep the amulet’s power from taking over. Her claws and fighting skills make her a capable teammate (and occasional friendly rival) for Spider-Man.